نوع مقاله : ﻣﻘﺎﻟﻪ ﮐﻮﺗﺎﻩ
عنوان مقاله English
نویسندگان English
Foot-and-mouth disease (FMD) is a major transboundary viral disease of cloven-hoofed animals, and vaccination with serological monitoring is essential for its control. This longitudinal field study evaluated short-term serological changes against Foot-and-Mouth Disease Virus (FMDV) serotype SAT1 in vaccinated Holstein calves.
Twelve clinically healthy, 4-month-old purebred Holstein female calves from a commercial dairy farm in Saveh, Iran, were included. All calves had received a single dose of a monovalent SAT1 vaccine (AFTOVAC®, VETAL, Turkey) 27 days before the initial blood sampling, and their dams had received three doses of FMD vaccine before calving. Serum antibodies against FMDV SAT1 were measured using an ELISA assay. Six calves (50%) were seropositive at the initial sampling and were resampled 21 days later.
At follow-up, all six previously seropositive calves became seronegative, with percentage positivity (PP) values below the assay cut-off, indicating a reduction in detectable antibodies during the study period.
Because of the small sample size and follow-up limited to initially seropositive calves, the findings should be interpreted cautiously and cannot be generalized to all vaccinated calves. Nevertheless, the study highlights the value of post-vaccination serological monitoring and the need for larger longitudinal studies to better understand antibody persistence following SAT1 vaccination.
کلیدواژهها English
